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Which one of the following statements is correct

> phenobarbital induces respiratory depression, which is enhanced by the consumption of ethanol

Anxiolytic:serotonin -1 A receptor sites

> buspirone  

Indicate ion channels are modulated by benzodiazepine derivatives

> chlorine

Which hypnotic drug has allosteric interaction with a macromolecular complex GAMK leads to more frequent opening of chloride channels

> phenazepam  

Effective drug in managing acute gouty arthritis ; also accelerates closure of patent ductus arteriosus in premature infants

> indomethacin

Aspirin: true answer

> inhibits cyclooxygenase

Mediator most likely to promote pain

> prostaglandins

NSAIDs such as aspirin can produce a type of allergic response in some patients. Which step, if blocked, is responsible for causing this drug allergy

> phospholypasa A-2  

The mechanism of action of montelukast involves

> leukotriene receptor antagonism

Highly selective COX-2 inhibitors are anti-inflammatory drugs with fewer GI side effects compared to aspirin.What other effect do COX -2 inhibitors lack in contrast to aspirin

> antiplatelet  

Mr.X has had history of hemophilia all of his life. He was recently diagnosed with gout. As his pharmacist, which of the following NSAIDs would you recommend

> celecoxib

The oxicams (piroxicam, tenoxicam and meloxicam) are similar to the salicylates EXCEPT they

> have less GI side effects

A patient presents with history of GI irritation and bleeding which of the following should you avoid prescribing

> aspirin

Which group of drugs reduces pain, anti-inflammatory effect and is used for peptic ulcers, enteritis, colitis

> astringents  

Mechanism of action of irritants drugs is

> stimulation of nerve ending of the skin

A patient on a diagnostic test for myasthenia gravis would be expected to have improved neuromuscular function after being treated with

> edrophonium  

A 75-year-old man who was a smoker is diagnosed with chronic obstructive pulmonary disease and suffers from occasional bronchospasm. Which of the following would be effective in treating him

> ipratropium aerosol

Which of the following may precipitate an attack of open-angle glaucoma if instilled into the eye

> atropine  

The prolonged apnea sometimes seen in patients who have undergone an operation in which succinylcholine was used as muscle relaxant has been shown to be due to

> depressed levels of plasma cholinesterase

A 50-year-old male farm worker is brought to the emergency room. He was found confused in the orchard and since then lost consciousness. His heart rate is 45, and his BP is 80/40mmHg.he is sweating and salivating profusely. Which of the following treatments is indicated?

> atropine