Which one of the following statements is correct
> phenobarbital induces respiratory depression, which is enhanced by the consumption of ethanol
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Showing posts from June, 2019
Indicate ion channels are modulated by benzodiazepine derivatives
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Which hypnotic drug has allosteric interaction with a macromolecular complex GAMK leads to more frequent opening of chloride channels
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Effective drug in managing acute gouty arthritis ; also accelerates closure of patent ductus arteriosus in premature infants
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NSAIDs such as aspirin can produce a type of allergic response in some patients. Which step, if blocked, is responsible for causing this drug allergy
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Highly selective COX-2 inhibitors are anti-inflammatory drugs with fewer GI side effects compared to aspirin.What other effect do COX -2 inhibitors lack in contrast to aspirin
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Mr.X has had history of hemophilia all of his life. He was recently diagnosed with gout. As his pharmacist, which of the following NSAIDs would you recommend
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The oxicams (piroxicam, tenoxicam and meloxicam) are similar to the salicylates EXCEPT they
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A patient presents with history of GI irritation and bleeding which of the following should you avoid prescribing
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Which group of drugs reduces pain, anti-inflammatory effect and is used for peptic ulcers, enteritis, colitis
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A patient on a diagnostic test for myasthenia gravis would be expected to have improved neuromuscular function after being treated with
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Which of the following may precipitate an attack of open-angle glaucoma if instilled into the eye
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The prolonged apnea sometimes seen in patients who have undergone an operation in which succinylcholine was used as muscle relaxant has been shown to be due to
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A 50-year-old male farm worker is brought to the emergency room. He was found confused in the orchard and since then lost consciousness. His heart rate is 45, and his BP is 80/40mmHg.he is sweating and salivating profusely. Which of the following treatments is indicated?
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Nondepolarizing neuromuscular blockers are associated with all of the following EXPECT
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Which of the following is not an expected symptom of poisoning with isoflurophate
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Which of following INCORRECTLY matches a cholinergic agonist with a pharmacological action
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Effects of anticholinesterase agents in therapeutic doses is
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Possible mechanism responsible for opioid –mediated flushing and warming of the skin
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Rational for I.V. morphine to manage dyspnea secondary to acute pulmonary edema
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Drug X produces maximal contraction of cardiac muscle in a manner similar to epinephrine (adrenaline). Drug X is considered to be a(n)
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What is the mistake in this prescription Rp.:Tabulettas Digoxini 0,00025 Da tales doses numero 10 Signa.1 tablet 3 times a day
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What is the mistake in this prescription Rp.:Solutionis Atropini sulfatis 0,1% - 10 ml Da.Signa:1 tablet 2 times a day
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Which of the following are the main purposes for adding a vasoconstrictor drug to a local anesthetic
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Which of the following are the main purposes for adding a vasoconstrictor drug to a local anesthetic
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A 14-year-old boy complained of burning pain due to multiple superficial skin abrasions. Which of the following local anesthetics would be appropriate for this boy
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Which of the following statements best explains why the onset of the therapeutic effect of a local anesthetic usually slower in infected tissues
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Which of the following molecular events makes the nerve membrane more sensitive to the action of local anesthetics
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Why benzocaine is not used for infiltration anesthesia
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What factor reduces the effect of procaine in the inflammation
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Specify the reason for the low activity of local anesthetics in inflammation
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Bulk flow of water through membrane pores, resulting from osmotic diffuses across the membrane, transport drug molecules that fit through the membrane pores
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A drug that rapidly combines with a receptor to initiate a response and rapidly dissociate or release from receptor is called a (an)
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Which of the following terms best defines a drug that binds to alpha adrenergic receptors, has no intrinsic activity, and cannot be displaced by epinephrine
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Two drugs act on the same tissue through independent receptors, resulting in effects in opposite directions. This is known as
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The situation when failure to continue administering the drug results in serious psychological and somatic disturbances is called
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What type of the interaction is associated with impaired of absorption, biotransformation, deposion and excreation of drugs
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If two drugs with the same effect, taken together, produce an effect that is equal in magnitude to the sum of the effects of the drugs given individually, it is called as
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Of the following characteristics, which is unlikely to be associated with the process of facilitated diffusion of drugs
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To the phenomena developing after repeated administration of medical substances is all, except
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You are reviewing the data from several meta-analysis that addressed the most common causes of adverse or otherwise excessive effects of prescription drugs in young adults and in elderly (>60 yeares of age).Interactions between multiple drugs were not considered. Which variable would you find to be decreased, and be the most common general cause of these problems, in the elders
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The degree of absorption of drugs when administered orally can be assessed by using this indicator
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When drug administrated enteral, then its bioavailability is determined by
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Types of drug transport through the membrane are all, EXCEPT
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What is typical for drugs that bound with plasma protein
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Changes of drugs under the influence of microsomal liver enzymes
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Changes of drugs under the influence of microsomal liver enzymes
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Changes of drugs under the influence of microsomal liver enzymes
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The rate of biotransformation of most drugs is increasing
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Metabolites that resulting from the biotransformation of drugs
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The area under the curve (AUC), reflecting dependence of time variation of a substance concentration in plasma after enteral administration
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How does change renal excretion of weak electrolytes when increased their ionization
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Factors that affecting to total clearance of drug substances
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What methods of drug administration doesn’t undergo by presystemic (first pass) elimination
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What methods of drug administration doesn’t undergo by presystemic (first pass) elimination
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What methods of drug administration doesn’t undergo by presystemic elimination
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Features of rectal route of drug administration compared with oral
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The substance most rapidly excreted from the body if it is in the kidneys
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For acceleration of substance excretion of the basic character from the body needs
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For acceleration of substance excretion of the acid character from the body needs
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The transfer of drugs through the membrane from the low concentration to a space with high concentration is called
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The main direction of biotransformation reaction with the participation of cytochrome P-450
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The drug gets into the blood stream, bypassing liver barrier, when used in the form
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The degree of drug binding with blood proteins DOES NOT depend on
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Hypoproteinemia leads to increased action of drugs, because
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Lipophilic drugs penetrate the membrane at a speed proportional to the concentration gradient and the distribution coefficient (lipid/water) in the following way
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Which parameter characterizes the amount of drug that entered to the systemic circulation
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Which parameter reflects the degree of clearance from drugs
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Correct statements listing characteristics of a parenteral route of drug administration include all of the following EXCEPT
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For the calculation of the volume of distribution (Vd) one must take into account
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Adverse effect on embryo unaccompanied by the development of congenital malformations is called
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Tick the antiviral drug which belongs to endogenous proteins
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The mechanism of action by which pyrantel pamoate is effective for treatment of Necator americanus (hookworm) is
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Thiabendazole, a benzimidazole derivative, is antihelminthic drug used primary to treat infections caused by
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The drug of choice for the treatment of T.saginata (tapeworm) is
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The drug of choice for treatment of Schistosoma haematobium is
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Tick the drug, blocking acetylcholine transmission at the myoneural junction of helminthes
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Tick the drug for nematodosis (roundworm invasion) treatment
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The mechanism of action of chloroquine in Plasmodium falciparum malaria is elimination of
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Which drug is used to suppress the erythrocytic phase of malaria
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Which drug is used to suppress the erythrocytic phase of malaria
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What is characteristic of active transport of drugs through membrane
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The absorption of drugs from intestine against the concentration gradient may be provided by
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The intensity of passive diffusion of drug substances through the cell membrane is determined by
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The intensity of passive diffusion of drug substances through membranes determined by
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What mediator causes elevation of hypothalamic set- point for temperature control
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Which mediators of inflammation are acted on by NSAIDs
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Histamine stimulates what type of cell in the stomach
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Which of the following is the most frequent side effect of H-1 antihistamines that is less common with second generation antihistamines
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Which one of following agents could significant impair the ability to drive an automobile
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What is the mechanism of antimicrobial action of potassium permanganate
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What antiseptic stimulates the respiratory center of the medulla
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What are some measures to be taken when using aminoglycosides
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What classes of drugs are: erythromycin and azithromycin
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Along with penicillin this line of drugs also contain a beta-lactam that is responsible for their antimicrobial activity
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What drug class are these ciprofloxacin and levofloxacin
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The greatest number of antimicrobic allergies is reported for what drug
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Which drug would not appropriate to treat the septicemia
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Antibacterials regarded as generally safe to prescribe in pregnancy
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Suitable for treatment of bacterial meningitis caused by H.influenzae
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Which fluoroquinolones is preferred to treat pneumonia
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Which of the following is not sensitive to fluoroquinolones
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Which of the following is not particularly sensitive to fluoroquinolones
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What is important adverse effects for fluoroquinolones
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Tick the drug, which is effective against only M.tuberculosis
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Tick the antimycobacterial drug belonging to first-line agents
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Tick the antitubercular drug, having the least activity
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Tick the antimycobacterial drug – hydrazide of isonicotinic acid
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Chronic candidiasis infections of the GI tract and oral cavity are treated with agent in pill form
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Which of the following drug belongs to polyene antifungal agents
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Which of the following drug is more effective for candidiasis
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Which of the following is the fungi static mechanism of action of griseofulvin
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Which of the following antifungal drug has anti-androgenic effects
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