Lipophilic drugs penetrate the membrane at a speed proportional to the concentration gradient and the distribution coefficient (lipid/water) in the following way
>simple diffusion
You are reviewing the data from several meta-analysis that addressed the most common causes of adverse or otherwise excessive effects of prescription drugs in young adults and in elderly (>60 yeares of age).Interactions between multiple drugs were not considered. Which variable would you find to be decreased, and be the most common general cause of these problems, in the elders
> renal function/clearance
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